Hsa-miR-520d Converts Fibroblasts into CD105+ Populations
نویسندگان
چکیده
منابع مشابه
Hsa-miR-520d Converts Fibroblasts into CD105+ Populations
BACKGROUND We have previously shown that hsa-miR-520d-5p can convert cancer cells into induced pluripotent stem cells (iPSCs) or mesenchymal stem cells (MSCs) via a dedifferentiation by a demethylation mechanism. METHODS We tested the effect of miR-520d-5p on human fibroblasts to determine whether it could be safely used in normal cells for future clinical therapeutic applications. After we t...
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The human ncRNA gene RGM249 regulates the extent of differentiation of cancer cells and the conversion of 293FT cells to hiPSCs. To identify the factors underlying this process, we investigated the effects of lentivirally inducing miR-520d expression in 293FT and HLF cells in vitro. Subsequently, we evaluated tumor formation in a xenograft model. Transformed HLF cells were Oct4 and Nanog positi...
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ژورنال
عنوان ژورنال: Drugs in R&D
سال: 2014
ISSN: 1174-5886,1179-6901
DOI: 10.1007/s40268-014-0064-6